Los artistas headliners del festival serán Black Sabbath, siendo esta la única fecha por Norteamérica para 2012, a la banda se le unen, Red Hot Chili Peppers, The Black Keys, Jack White, Justice & Avicii.
A continuación detallamos el cartel de acuerdo al diario Chicago Sun-Times:
At the Drive-In, Sigur Rós, Florence and the Machine, The Shins, The Afghan Whigs, The Weeknd, M83, Passion Pit, Bloc Party, Franz Ferdinand, Frank Ocean, Childish Gambino, Miike Snow, The Gaslight Anthem, Alabama Shakes, J. Cole, y Metric.
Tambien se han confirmado la presencia de: Delta Spirit, tUnE-yArDs, The Tallest Man on Earth, Die Antwoord, Dr. Dog, Dawes, SBTRKT, The Walkmen, Neon Indian, Gary Clark Jr., Sharon Van Etten, Polica, The War on Drugs, Doomtree, White Rabbits, Washed Out, Of Monsters and Men, Tame Impala, Neon Indian, Bowerbirds, The Temper Trap, The Black Angels, Bear In Heaven, Chairlift, Oberhofer, First Aid Kit, y JEFF the Brotherhood.
En el escenario electrónico se presentarán: Bassnectar, Kaskade, Santigold, Calvin Harris, Nero, Knife Party, Little Dragon, Skream & Benga, Zeds Dead, Big Gigantic, Sub Focus, Porter Robinson, y Star Slinger.